Reproductive health,
formulated with rigor.

DHEA is an adrenal androgen involved in early follicle development. Several retrospective studies and meta-analyses in women with diminished ovarian reserve report higher clinical pregnancy rates following DHEA pretreatment before IVF, though the effect on the number of eggs retrieved is less consistent, and the largest randomized trials show a smaller benefit than the observational data. We formulated to the micronized dose used in most of this research rather than to a rounder, more marketable number.

Egg and sperm cells are unusually energy-intensive, and mitochondrial output in both declines with age. Laboratory work has shown that restoring CoQ10 levels can reverse age-related mitochondrial decline in oocytes, and clinical reviews report improved ovarian response and embryo quality with CoQ10 pretreatment in women with weaker ovarian reserve. The evidence base is genuinely promising rather than settled — most authors are still calling for larger randomized trials, and we think that distinction matters more than a confident marketing claim would.

Vitamin D receptors are present in both testes and ovarian tissue, and population studies consistently find lower vitamin D status in infertile men and women compared with fertile controls, alongside associations with sperm motility and morphology. Vitamin K2 is included because it governs how the body uses the calcium that vitamin D helps absorb, and animal work links K2 deficiency to reduced sperm count and motility. Trial results for supplementation are more mixed than the observational data, which is typical for a nutrient this broadly involved in physiology.

Folate is the best-established nutrient in reproductive health: umbrella reviews of decades of trial and cohort data show that periconceptional folic acid and multivitamin use meaningfully lowers the risk of neural tube defects, which is why clinical guidelines recommend it before conception rather than after a positive test. We built the multivitamin around that same preconception window, so the foundational nutrients are on board before they're needed rather than after.

Resveratrol is an antioxidant studied for its ability to reduce oxidative stress in the granulosa cells that support a developing egg, with animal work linking it to better oocyte quality and a longer ovarian lifespan. Human evidence is genuinely split: some trials report better oocyte maturation, while one large retrospective study of IVF cycles found lower pregnancy rates at higher intake, likely tied to effects on the uterine lining rather than the egg itself. We formulate at the lower end of studied doses for that reason, and see this as the product to discuss with a doctor if pregnancy is imminent.

Folic acid's role in preventing neural tube defects is one of the most replicated findings in reproductive medicine, dating back to the landmark Medical Research Council trial that halved recurrence risk in high-risk pregnancies. Because the neural tube closes before most people know they're pregnant, the protective window falls before conception — which is why we offer folic acid as its own product for anyone building a stack around it rather than a bundled multivitamin.